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BAY 1892005

Chemical Structure : BAY 1892005

CAS No.: 2036352-13-1

BAY 1892005 (BAY1892005)

Catalog No.: PC-49086Not For Human Use, Lab Use Only.

BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C。
BAY 1892005 exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values.

Physicochemical Properties

M.Wt 270.706
Formula C11H8ClFN2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-chloro-N-(4-(2-fluorophenyl)thiazol-2-yl)acetamide

References

1. Clara Lemos, et al. iScience. 2020 Sep 25; 23(9): 101517.

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