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Chemical Structure : UCI-LC0019
Catalog No.: PC-49217Not For Human Use, Lab Use Only.
UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.
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UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.
UCI-LC0019 rapidly induced apoptosis compare with APR-246.
UCI-LC0019 exhibits significantly increased solubility while maintaining activity and selectivity compare with UCI-LC0023.
UCI-LC0019 (3.3 mg/kg, 10 mg/kg, i.p.) exerted anti-tumor effect in tumor models, treatment with UCI-LC0019 resulted in a significant reduction of tumor volume in p53R175H carrying TOV112D tumors, did not significantly inhibit the growth of TOV112Dp53 / or HCT116 (p53 +/+) tumors.
| M.Wt | 278.311 | |
| Formula | C17H14N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Geetha Durairaj, et al. Cell Chem Biol. 2022 Aug 9;S2451-9456(22)00275-6.
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