Chemical Structure : Morncide
CAS No.:
Morncide
(CPP-Morn3 (222-237))
Catalog No.: PC-49198Not For Human Use, Lab Use Only.
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells.
Morncide (CPP-Morn3 (222-237)) efficiently increases p53 expression and acetylation, causing substantial decrease in p53 ubiquitination in cultured CRC cells, displays dose-dependent upregulation of CDKN1A, BAX, and NOXA.
Morncide increases p53 expression and acetylation, causing significant induction of p21 expression in tumor tissue, decreases tumor growth in mice carrying HCT116 (wild-type p53) xenograft tumors.
The Morn3 gene encodes a MORN (membrane occupation and recognition nexus) repeats-containing protein that is 240 amino acids in length.
Morn3 is a cancer/testis antigen with oncogenic functions, assembles a protein complex to regulate composite modifications of p53.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Sequence: PDGVL AEALA MFRKT E
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References
1. Lunxi Liang, et al. Cell Chem Biol. 2018 Jun 21;25(6):761-774.e5.
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