| Cat. No. |
Product Name |
Information |
| PC-60441 |
AM-8553
MDM2-p53 inhibitor
|
AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM. |
| PC-60440 |
AM-6761
MDM2-p53 inhibitor
|
AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties. |
| PC-60439 |
TDP-665759
HDM2-p53 inhibitor
|
TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM. |
| PC-60438 |
NU-8165
MDM2-p53 inhibitor
|
NU-8165 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM. |
| PC-60437 |
NU-8231
MDM2-p53 inhibitor
|
NU-8231 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay. |
| PC-60436 |
WK-298
Mdm2-MdmX inhibitor
|
WK-298 (Novartis 101) is a potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively. |
| PC-60304 |
RO-5353
p53-MDM2 inhibitor
|
RO-5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM. |
| PC-60303 |
RO-2468
p53-MDM2 inhibitor
|
RO-2468 (RO2468) potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM. |
| PC-60302 |
DS-3032
MDM2 inhibitor
|
Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
| PC-60301 |
BI-0252
MDM2-p53 inhibitor
|
BI-0252 is a potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM. |
| PC-60218 |
CB-002
p53 activator
|
CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts. |
| PC-60182 |
MPK-09
p53 reactivator
|
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator. |
