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Request The Product List ofMDM2-p53 MDM2-p53

Cat. No. Product Name Information
PC-60466

CTX-1

p53-HdmX inhibitor

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
PC-60462

SP 141

MDM2 inhibitor

A novel specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation.
PC-60443

RO-5963

Mdm2-MdmX inhibitor

RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.
PC-60442

AM-8735

MDM2-p53 inhibitor

AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.
PC-60441

AM-8553

MDM2-p53 inhibitor

AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.
PC-60440

AM-6761

MDM2-p53 inhibitor

AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.
PC-60439

TDP-665759

HDM2-p53 inhibitor

TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.
PC-60438

NU-8165

MDM2-p53 inhibitor

NU-8165 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM.
PC-60437

NU-8231

MDM2-p53 inhibitor

NU-8231 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.
PC-60436

WK-298

Mdm2-MdmX inhibitor

WK-298 (Novartis 101) is a potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively.
PC-60304

RO-5353

p53-MDM2 inhibitor

RO-5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.
PC-60303

RO-2468

p53-MDM2 inhibitor

RO-2468 (RO2468) potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.

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