| Cat. No. |
Product Name |
Information |
| PC-45588 |
SAR405838
p53-MDM2 inhibitor
|
SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM. |
| PC-44349 |
Nutlin-3b
p53-MDM2 inhibitor
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
| PC-42287 |
MX69
MDM2 inhibitor
|
MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO8994
p53-MDM2 inhibitor
|
RO8994 (RO 8994) is a highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
| PC-45048 |
Pifithrin-β hydrobromide
p53 inhibitor
|
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-27805 |
NSC146109 hydrochloride
MDMX inhibitor, p53 activator
|
NSC146109 (XI-011) hydrochloride is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |
| PC-27559 |
MI-888
MDM2 inhibitor
|
MI-888 is an orally active MDM2 inhibitor with Ki of 0.44 nM, inhibit the MDM2-p53 interaction. |
| PC-27558 |
MI-1061
MDM2 inhibitor
|
MI-1061 is a potent and efficacious MDM2 inhibitor with binding IC50 of 4.4 nM and Ki of 0.16 nM. |
| PC-27031 |
DIMP53-1
p53-MDM2/X inhibitor, p53 activator
|
DIMP53-1 is a novel p53 activator and dual inhibitor of the p53-MDM2/X, inhibits the p53-MDM2/X interactions by potentially binding to p53. |
| PC-26507 |
LLQ-45
p53 Y220C agonist
|
LLQ-45 is a novel covalent agonist for p53 Y220C, restores the DNA-binding ability of p53 Y220C with EC50 of 24.97 uM, shows selective anti-proliferative activity against p53 Y220C. |
| PC-26155 |
Amifostine
Radioprotector
|
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector, protects normal tissues from damage caused by radiation and chemotherapy, also is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. |
