| Cat. No. |
Product Name |
Information |
| PC-42287 |
MX69
MDM2 inhibitor
|
MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO8994
p53-MDM2 inhibitor
|
RO8994 (RO 8994) is a highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
| PC-45048 |
Pifithrin-β hydrobromide
p53 inhibitor
|
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-27559 |
MI-888
MDM2 inhibitor
|
MI-888 is an orally active MDM2 inhibitor with Ki of 0.44 nM, inhibit the MDM2-p53 interaction. |
| PC-27558 |
MI-1061
MDM2 inhibitor
|
MI-1061 is a potent and efficacious MDM2 inhibitor with binding IC50 of 4.4 nM and Ki of 0.16 nM. |
| PC-27031 |
DIMP53-1
p53-MDM2/X inhibitor, p53 activator
|
DIMP53-1 is a novel p53 activator and dual inhibitor of the p53-MDM2/X, inhibits the p53-MDM2/X interactions by potentially binding to p53. |
| PC-26507 |
LLQ-45
p53 Y220C agonist
|
LLQ-45 is a novel covalent agonist for p53 Y220C, restores the DNA-binding ability of p53 Y220C with EC50 of 24.97 uM, shows selective anti-proliferative activity against p53 Y220C. |
| PC-26155 |
Amifostine
Radioprotector
|
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector, protects normal tissues from damage caused by radiation and chemotherapy, also is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. |
| PC-26154 |
Amifostine thiol
Radioprotector
|
Amifostine thiol (Amitiotine, WR-1065) is an active metabolite of the cytoprotector Amifostine, which is a broad-spectrum cytoprotective agent and a radioprotector, activates p53 through a JNK-dependent signaling pathway. |
| PC-26088 |
NSC207895
MDMX inhibitor, p53 activator
|
NSC207895 (XI-006) is a small-molecule inhibitor of MDMX (MDM4) and p53 activator, activates p53 and induces apoptosis, inhibits MDMX expression in cancer cells. |
| PC-25969 |
PK11000
Y220C p53 reactivator
|
PK11000 is a small molecule allosteric disruptor Y220C and Y220C p53 reactivator, reactivates p53 native function in Y220C mutant present tumors. |
