Chemical Structure : MX69-102
CAS No.:
2627019-77-4
MX69-102
Catalog No.: PC-22898Not For Human Use, Lab Use Only.
MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
MX69-102 does not bind to MDM2 with deletion of the RING.
MX69-102 potently downregulated MDM2 in MDM2-overexpressing ALL cell lines.
MX69-102 mediated MDM2 downregulation, leading to activation of p53 and inhibition of XIAP.
MX69-102 shows potent inhibitory and apoptotic effects on MDM2-overexpressing ALL in vitro.
MX69-102 exhibits minimal or no cytotoxic or inhibitory effect on normal human hematopoiesis.
MX69-102 also shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice.
Physicochemical Properties
|
M.Wt
|
518.63
|
|
Formula
|
C29H30N2O5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(3aS,4R,9bS)-N-(4-acetylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide
|
References
1. Tao Liu, et al. Cancer Lett. 2024 Jul 23:598:217126.
Contact Us
sales@probechem.com
