Chemical Structure : MX69-102
CAS No.:
2627019-77-4
MX69-102
Catalog No.: PC-22898Not For Human Use, Lab Use Only.
MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
MX69-102 does not bind to MDM2 with deletion of the RING.
MX69-102 potently downregulated MDM2 in MDM2-overexpressing ALL cell lines.
MX69-102 mediated MDM2 downregulation, leading to activation of p53 and inhibition of XIAP.
MX69-102 shows potent inhibitory and apoptotic effects on MDM2-overexpressing ALL in vitro.
MX69-102 exhibits minimal or no cytotoxic or inhibitory effect on normal human hematopoiesis.
MX69-102 also shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice.
Physicochemical Properties
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M.Wt
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518.63
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Formula
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C29H30N2O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3aS,4R,9bS)-N-(4-acetylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide
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References
1. Tao Liu, et al. Cancer Lett. 2024 Jul 23:598:217126.
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