| Cat. No. |
Product Name |
Information |
| PC-70044 |
NSC-66811
MDM2-p53 inhibitor
|
NSC-66811 (NSC 66811) is a potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells. |
| PC-70006 |
PhiKan 083
p53 reactivator
|
PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
| PC-70003 |
HDM-201
p53-MDM2 inhibitor
|
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM. |
| PC-45010 |
SJ-172550
MDMX inhibitor
|
SJ-172550 (SJ172550) is the first small molecule MDMX inhibitor that reversibly binds the p53-binding pocket of MDMX, disrupts MDMX-p53 interaction with EC50 of 2.3 uM. |
| PC-42100 |
Nutlin-3a
p53-MDM2 inhibitor
|
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. |
| PC-45497 |
NSC319726
p53R175 reactivator
|
NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant. |
| PC-45773 |
PRIMA-1
p53 reactivator
|
PRIMA-1 (PRIMA1) is a specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines. |
| PC-45688 |
NSC59984
p53 activator
|
NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells. |
| PC-45613 |
Tenovin-3
p53 activator
|
Tenovin-3 is a sirtuin inhibitor that increases p53 levels in MCF-7 cells. |
| PC-45845 |
Nutlin-3
p53-MDM2 inhibitor
|
Nutlin-3 (Nutlin 3) is a potent and selective Mdm2 inhibitor with IC50 of 90 nM. |
| PC-42750 |
RG7112
p53-MDM2 inhibitor
|
RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM). |
| PC-45588 |
SAR405838
p53-MDM2 inhibitor
|
SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM. |
