| Cat. No. |
Product Name |
Information |
| PC-60302 |
DS-3032
MDM2 inhibitor
|
Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
| PC-60301 |
BI-0252
MDM2-p53 inhibitor
|
BI-0252 is a potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM. |
| PC-60218 |
CB-002
p53 activator
|
CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts. |
| PC-60182 |
MPK-09
p53 reactivator
|
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator. |
| PC-70044 |
NSC-66811
MDM2-p53 inhibitor
|
NSC-66811 (NSC 66811) is a potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells. |
| PC-70006 |
PhiKan 083
p53 reactivator
|
PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
| PC-70003 |
HDM-201
p53-MDM2 inhibitor
|
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM. |
| PC-45010 |
SJ-172550
MDMX inhibitor
|
SJ-172550 (SJ172550) is the first small molecule MDMX inhibitor that reversibly binds the p53-binding pocket of MDMX, disrupts MDMX-p53 interaction with EC50 of 2.3 uM. |
| PC-42100 |
Nutlin-3a
p53-MDM2 inhibitor
|
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. |
| PC-43699 |
Quinacrine dihydrochloride
HNMT inhibitor, p53 inducer
|
Quinacrine dihydrochloride (Mepacrine dihydrochloride, SN-390) is an antiprotozoal, antirheumatic and intrapleural sclerosing agen, inhibits histamine N-methyltransferase (HNMT), |
| PC-45497 |
NSC319726
p53R175 reactivator
|
NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant. |
| PC-45773 |
PRIMA-1
p53 reactivator
|
PRIMA-1 (PRIMA1) is a specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines. |
