PhiKan 083 |CAS:1050480-30-2 Probechem Biochemicals

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Chemical Structure : PhiKan 083

CAS No.: 1050480-30-2

PhiKan 083 (PK-083, PhiKan-083)

Catalog No.: PC-70006Not For Human Use, Lab Use Only.

PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.

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5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.
PhiKan 083 binds with high affinity to a crevice created by the Y220C mutation in p53 and stabilizes the mutant protein.

Physicochemical Properties

M.Wt	274.792
Formula	C16H18N2.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride

References

1. Bauer MR, et al. ACS Chem Biol. 2016 Aug 19;11(8):2265-74.

2. Boeckler FM, et al. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.

3. Wiman KG. Oncogene. 2010 Jul 29;29(30):4245-52.

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PhiKan 083 (PK-083, PhiKan-083)

Biological Activity

Physicochemical Properties

References

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