| Cat. No. |
Product Name |
Information |
| PC-60262 |
MK-8242
|
A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction. |
| PC-60182 |
MPK-09
|
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator. |
| PC-70044 |
NSC-66811
|
A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.. |
| PC-70006 |
PhiKan-083
|
A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
| PC-45010 |
SJ-172550
|
The first small molecule MDMX inhibitor that reversibly binds the p53-binding pocket of MDMX, disrupts MDMX-p53 interaction with EC50 of 2.3 uM.. |
| PC-45773 |
PRIMA-1
|
A specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines. |
| PC-45613 |
Tenovin-3
|
A sirtuin inhibitor that increases p53 levels in MCF-7 cells.. |
| PC-45845 |
Nutlin-3
|
A potent and selective Mdm2 inhibitor with IC50 of 90 nM. |
| PC-42750 |
RG7112
|
A potent and selective inhibitor of p53-MDM2 interaction. |
| PC-44349 |
Nutlin-3b
|
A p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. . |
| PC-42287 |
MX69
|
A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO-8994
|
A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
