| Cat. No. |
Product Name |
Information |
| PC-44349 |
Nutlin-3b
p53-MDM2 inhibitor
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
| PC-42287 |
MX69
MDM2 inhibitor
|
MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO-8994
p53-MDM2 inhibitor
|
A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
| PC-45048 |
Pifithrin-β hydrobromide
p53 inhibitor
|
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-22247 |
Pifithrin-α hydrobromide
p53 inhibitor
|
Pifithrin-α hydrobromide is a small molecule inhibitor of p53, blocks its transcriptional activity and prevents cells from apoptosis, also is an aryl hydrocarbon receptor (AhR) agonist. |
| PC-21746 |
NSC146109
MDM4 inhibitor
|
NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |
| PC-21238 |
DS-3032 tosylate hydrate
MDM2-p53 inhibitor
|
Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
| PC-20688 |
MMRi71
MDM2-MDM4 E3 ligase inhibitor
|
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells. |
| PC-20687 |
MMRi67
MDM2-MDM4 E3 ligase inhibitor
|
MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM. |
| PC-20668 |
BI-907828
MDM2 inhibitor
|
BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53. |
| PC-20010 |
J012-3168
RPL11-MDM2 inhibitor
|
RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation. |
