| Cat. No. |
Product Name |
Information |
| PC-45688 |
NSC59984
p53 activator
|
NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells. |
| PC-45613 |
Tenovin-3
p53 activator
|
Tenovin-3 is a sirtuin inhibitor that increases p53 levels in MCF-7 cells. |
| PC-45845 |
Nutlin-3
p53-MDM2 inhibitor
|
Nutlin-3 (Nutlin 3) is a potent and selective Mdm2 inhibitor with IC50 of 90 nM. |
| PC-42750 |
RG7112
p53-MDM2 inhibitor
|
RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM). |
| PC-45588 |
SAR405838
p53-MDM2 inhibitor
|
SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM. |
| PC-44349 |
Nutlin-3b
p53-MDM2 inhibitor
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
| PC-42287 |
MX69
MDM2 inhibitor
|
MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO-8994
p53-MDM2 inhibitor
|
A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
| PC-45048 |
Pifithrin-β hydrobromide
p53 inhibitor
|
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-23521 |
TRAP-1
p53 activator
|
TRAP-1 is a small molecule chemical inducer of proximity that activates mutant p53, engages mutant p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. |
| PC-23284 |
PG3-Oc
p53 activator, ATF4 activator
|
PG3-Oc is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 31 nM. |
