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Chemical Structure : MX69
CAS No.: 1005264-47-0
Catalog No.: PC-42287Not For Human Use, Lab Use Only.
A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $96 | In stock | |
| 10 mg | $152 | In stock | |
| 50 mg | $608 | In stock | |
| 100 mg | $1040 | In stock |
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A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM; induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells; shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.
| M.Wt | 474.57134 | |
| Formula | C27H26N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
4-{8-[(3,4-Dimethylphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid |
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1. Gu L, et al. Cancer Cell. 2016 Oct 10;30(4):623-636.
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