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MX69

Chemical Structure : MX69

CAS No.: 1005264-47-0

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MX69 (MDM2 inhibitor, MX-69)

Catalog No.: PC-42287Not For Human Use, Lab Use Only.

MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.

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10 mg $98 In stock
25 mg $158 In stock
50 mg $248 In stock
100 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.
MX69 induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells.
MX69 shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.

Physicochemical Properties

M.Wt 474.57134
Formula C27H26N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

4-{8-[(3,4-Dimethylphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid

References

1. Gu L, et al. Cancer Cell. 2016 Oct 10;30(4):623-636.

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