Nutlin-3b |CAS:675576-97-3 Probechem Biochemicals

Chemical Structure : Nutlin-3b

CAS No.: 675576-97-3

Nutlin-3b (Nutlin 3b)

Catalog No.: PC-44349Not For Human Use, Lab Use Only.

Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

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Biological Activity

Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

Physicochemical Properties

M.Wt	581.4896
Formula	C30H30Cl2N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-

References

1. Vassilev LT, et al. Science, 2004, 303(5659), 844-848.

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Nutlin-3b (Nutlin 3b)

Biological Activity

Physicochemical Properties

References

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