Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-MDM2-p53-Pifithrin-β hydrobromide
Pifithrin-β hydrobromide

Chemical Structure : Pifithrin-β hydrobromide

CAS No.: 511296-88-1

Pifithrin-β hydrobromide (Cyclic Pifithrin-α hydrobromide;PFT-β hydrobromide)

Catalog No.: PC-45048Not For Human Use, Lab Use Only.

Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
Pifithrin-β hydrobromide prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
Pifithrin-β hydrobromide sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.

Physicochemical Properties

M.Wt 349.2886
Formula C16H17BrN2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 26 mg/mL

Chemical Name/SMILES

Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)

References

1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.

2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.

3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: