Chemical Structure : Pifithrin-β hydrobromide
CAS No.: 511296-88-1
Catalog No.: PC-45048Not For Human Use, Lab Use Only.
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
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Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
Pifithrin-β hydrobromide prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
Pifithrin-β hydrobromide sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
M.Wt | 349.2886 | |
Formula | C16H17BrN2S | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: 26 mg/mL |
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Chemical Name/SMILES |
Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1) |
1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.
3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
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