RO-8994 |CAS:1309684-94-3 Probechem Biochemicals

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Chemical Structure : RO-8994

CAS No.: 1309684-94-3

RO-8994 (RO8994)

Catalog No.: PC-45124Not For Human Use, Lab Use Only.

A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.

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25 mg	$228	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RO-8994 (RO8994) is a highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.
RO-8994 shows marked improvement in both in vitro and in vivo pharmacological properties.

Physicochemical Properties

M.Wt	613.5067
Formula	C31H31Cl2FN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-

References

1. Zhang Z, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9.

2. Yu B, et al. Anticancer Agents Med Chem. 2016;16(10):1315-24.

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RO-8994 (RO8994)

Biological Activity

Physicochemical Properties

References

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