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Chemical Structure : PRIMA-1
CAS No.: 5608-24-2
Catalog No.: PC-45773Not For Human Use, Lab Use Only.
A specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 25 mg | $120 | In stock | |
| 50 mg | $176 | In stock | |
| 100 mg | $320 | In stock |
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A specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines; is efficacious against myeloma cells with differential p53 genotypes, causes the demethylation of TP73, through DNMT1 depletion, to subsequently enhance UPR; selectively induces apoptosis and cell cycle arrest in p53 mutant cells compared to CAPAN-2 cells.
Blood Cancer
Phase 2 Clinical
| M.Wt | 185.2203 | |
| Formula | C9H15NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 44 mg/mL |
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| Chemical Name/SMILES |
1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)- |
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1. Izetti P, et al. Invest New Drugs. 2014 Oct;32(5):783-94.
2. Bykov VJ, et al. Carcinogenesis. 2002 Dec;23(12):2011-8.
3. Teoh PJ, et al. Oncotarget. 2016 Sep 20;7(38):61806-61819.
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