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Chemical Structure : Nutlin-3
CAS No.: 890090-75-2
Catalog No.: PC-45845Not For Human Use, Lab Use Only.
A potent and selective Mdm2 inhibitor with IC50 of 90 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $360 | In stock | |
| 100 mg | $624 | In stock |
Bulk size, bulk discount!
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A potent and selective Mdm2 inhibitor with IC50 of 90 nM; binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice; induces p53 and p21WAF expression in a dose-dependent manner in 22RV1 cells; also can block the MDMX–p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0.7 uM.
| M.Wt | 581.4896 | |
| Formula | C30H30Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel- |
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1. Vassilev LT, et al. Science. 2004 Feb 6;303(5659):844-8.
2. Supiot S, et al. Mol Cancer Ther. 2008 Apr;7(4):993-9.
3. Laurie NA, et al. Nature, 2006, 444(7115), 61-66.
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