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NSC319726

Chemical Structure : NSC319726

CAS No.: 71555-25-4

NSC319726 (NSC 319726, ZMC1)

Catalog No.: PC-45497Not For Human Use, Lab Use Only.

NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant.
NSC319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.

Physicochemical Properties

M.Wt 234.3207
Formula C11H14N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 27.5 mg/mL

Chemical Name/SMILES

1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide

References

1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25.

2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92.

3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575.

4. Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.

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