| Cat. No. |
Product Name |
Information |
| PC-38124 |
NSC194598
p53 inhibitor
|
NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo. |
| PC-38075 |
H210
Mdm2/MdmX inhibitor
|
H210 is a potent dual Mdm2/MdmX inhibitor with Ki of 9.66/2.89 nM, respectively.. |
| PC-38074 |
H203
Mdm2/MdmX inhibitor
|
H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively. |
| PC-35309 |
MB710
p53 Y220C reactivator
|
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.. |
| PC-35308 |
MB725
p53 Y220C reactivator
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
| PC-42959 |
AMG 232
MDM2-p53 inhibitor
|
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM. |
| PC-42949 |
YH239-EE
MDM2-p53 inhibitor
|
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4. |
| PC-42840 |
Serdemetan
HDM2 inhibitor
|
Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM. |
| PC-63188 |
AQ-101
MDM2 degrader
|
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
| PC-62777 |
RETRA
p53 activator
|
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
| PC-62555 |
MMRi6
Mdm2-MdmX inhibitor
|
MMRi6 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.. |
| PC-62554 |
MMRi64
Mdm2-MdmX inhibitor
|
MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells. |
