| Cat. No. |
Product Name |
Information |
| PC-49512 |
GY1-22
DNAJA1-mutp53R175H inhibitor
|
GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation. |
| PC-49493 |
UC2288
p21 inhibitor
|
UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription. |
| PC-49217 |
UCI-LC0019
mutant p53 reactivator
|
UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49216 |
UCI-LC0023
mutant p53 reactivator
|
UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49198 |
Morncide
p53-Morn3 inhibitor
|
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells. |
| PC-49087 |
BAY 249716
p53 modulator
|
BAY 249716 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C. |
| PC-49086 |
BAY 1892005
p53 modulator
|
BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values. |
| PC-38473 |
Inauhzin
p53 activator, SIRT1 inhibitor
|
Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
| PC-72830 |
MMRi62
Ferroptosis inducer, MDM2-MDM4 inhibitor
|
MMRi62 is a small molecule ferroptosis inducer and MDM2-MDM4-targeting chemical with p53-independent pro-apoptotic activity. |
| PC-72829 |
ALRN-6924
MDM2/MDMX inhibitor
|
Sulanemadlin (ALRN-6924, MP-4897) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. |
| PC-72590 |
ReACp53
p53 mutants rescuer
|
ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines. |
| PC-72589 |
ADH-6
p53 mutants rescuer
|
ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W). |
