Cat. No. |
Product Name |
Information |
PC-62406 |
APR-246
p53 modulator
|
APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. |
PC-61496 |
DIMP53-1
|
DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM. |
PC-61494 |
COTI-2
|
COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway. |
PC-61324 |
HL001
Cyclophilin A inhibitor
|
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
PC-60302 |
DS-3032
MDM2 inhibitor
|
Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
PC-60218 |
CB-002
|
CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts. |
PC-70003 |
HDM-201
MDM2 inhibitor
|
HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM. |
PC-42100 |
Nutlin-3a
|
Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. |
PC-45497 |
NSC-319726
|
NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator. |
PC-45688 |
NSC-59984
|
NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells. |
PC-45588 |
SAR-405838
|
SAR-405838(MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM. |
PC-21746 |
NSC146109
MDM4 inhibitor
|
NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |