You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-MDM2-p53

Request The Product List ofMDM2-p53 MDM2-p53

Cat. No. Product Name Information
PC-62406

APR-246

p53 modulator

APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
PC-61496

DIMP53-1

DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.
PC-61494

COTI-2

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.
PC-61324

HL001

Cyclophilin A inhibitor

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.
PC-60302

DS-3032

MDM2 inhibitor

Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
PC-60218

CB-002

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
PC-70003

HDM-201

MDM2 inhibitor

HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
PC-42100

Nutlin-3a

Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
PC-45497

NSC-319726

NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
PC-45688

NSC-59984

NSC59984 is a small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells.
PC-45588

SAR-405838

SAR-405838(MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM.
PC-21746

NSC146109

MDM4 inhibitor

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com