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MB725

Chemical Structure : MB725

CAS No.: 2230058-99-6

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MB725 (MB-725)

Catalog No.: PC-35308Not For Human Use, Lab Use Only.

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM)。
    MB725 caused reduction of viability correlated with increased and selective transcription of p53 target genes such as BTG2, p21, PUMA, FAS, TNF, and TNFRSF10B, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the Y220C mutant.

    Physicochemical Properties

    M.Wt 484.356
    Formula C18H21IN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide

    References

    1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.

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