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H203

Chemical Structure : H203

CAS No.:

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H203 (dual Mdm2/MdmX inhibitor H203)

Catalog No.: PC-38074Not For Human Use, Lab Use Only.

H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.
    H203 significantly reduced cell viability in the cells overexpressing both Mdm2 and MdmX, and a significant and dose-dependent decrease in cell number in H203-treated cells lacking Mdm2 or MdmX.
    H203-mediated decrease in cell viability is strictly p53-dependent and H203 affects MdmX more specifically than nutlin-3a.
    H203 induced the expression of the p21 gene but not the p53 gene in treated cancer cells.

    Physicochemical Properties

    M.Wt 667.547
    Formula C35H28Cl2N6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-((4S,5R)-4,5-bis(4-chlorophenyl)-1-(3-oxopiperazine-1-carbonyl)-4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

    References

    1. Xiyao Cheng, et al. Nat Commun. 2022 Feb 28;13(1):1087.

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