ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines.
ReACp53 inhibits p53 aggregation in primary cells from HGSOC patients, and re-localizes p53 to the nucleus in an active conformation.
ReACp53 induces cancer cell death, cell cycle arrest and results in p53 degradation.
ReACp53 induces rapid cell death in human primary uterine fibroblasts transfected with a dominant negative R175H p53 mutant grown in 3D.
ReACp53 specifically affects cell viability and proliferation of cancer cells bearing mutant p53 but not wild type when grown as organoids.
ReACp53 causes regression of xenografts bearing an aggregation-prone p53 mutant in HGSOC xenograft models.
ReACp53 is well tolerated, causes regression of intraperitonal disseminated tumors in vivo.
