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YH239-EE

Chemical Structure : YH239-EE

CAS No.: 1364488-67-4

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YH239-EE (YH 239-EE;YH 239 EE)

Catalog No.: PC-42949Not For Human Use, Lab Use Only.

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.
YH239-EE induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.

Physicochemical Properties

M.Wt 504.4056
Formula C25H27Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 55 mg/mL
Chemical Name/SMILES

1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester

References

1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.

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