Catalog No.: PC-72829Not For Human Use, Lab Use Only.
ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions.
ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions.
ALRN-6924 demonstrated potent anti-proliferative activity in a dose-dependent manner in two ER+ cell lines with WT TP53, MCF-7 and ZR-75-1, with IC50 values of 113 nM and 500 nM respectively.
The combination of ALRN-6924 and chemotherapeutic agents synergistically inhibit cell proliferation in vitro, ALRN-6924 combined with paclitaxel reactivates p53 and induces cell cycle arrest and apoptosis in vitro.
ALRN-6924 mutually enhances both paclitaxel and eribulin antitumor efficacy and inhibits tumor growth in vivo.
