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Chemical Structure : NSC194598
Catalog No.: PC-38124Not For Human Use, Lab Use Only.
NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo.
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NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50 = 180 nM) and in vivo.
NSC194598 selectively inhibits DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc.
NSC194598 inhibits p53 DNA binding and induction of target genes.
NSC194598 apparently acts by binding to the DNA-binding domain of p53, and shows specificity against several control transcription factors.
NSC194598 suppresses p53 transcriptional output after DNA damage in culture and increases the survival of mice after irradiation.
| M.Wt | 317.39 | |
| Formula | C20H21N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qingliang Li, et al.Oncogene. 2020 Jul;39(29):5187-5200.
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