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NSC194598

Chemical Structure : NSC194598

CAS No.: 5358-76-9

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NSC194598 (NSC 194598)

Catalog No.: PC-38124Not For Human Use, Lab Use Only.

NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50 = 180 nM) and in vivo.
    NSC194598 selectively inhibits DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc.
    NSC194598 inhibits p53 DNA binding and induction of target genes.
    NSC194598 apparently acts by binding to the DNA-binding domain of p53, and shows specificity against several control transcription factors.
    NSC194598 suppresses p53 transcriptional output after DNA damage in culture and increases the survival of mice after irradiation.

    Physicochemical Properties

    M.Wt 317.39
    Formula C20H21N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide

    References

    1. Qingliang Li, et al. Oncogene. 2020 Jul;39(29):5187-5200.

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