RO-2468 |Cas:1360821-21-1 Probechem Biochemicals

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Chemical Structure : RO-2468

RO-2468 (RO 2468;RO2468)

Catalog No.: PC-60303Not For Human Use, Lab Use Only.

RO-2468 (RO2468) potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RO-2468 (RO2468) potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
RO-2468 exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994.
RO-2468 displays tumor regression in tumor models at 10 mg/kg.

Physicochemical Properties

M.Wt	614.499
Formula	C30H30Cl2FN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide

References

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.

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RO-2468 (RO 2468;RO2468)

Biological Activity

Physicochemical Properties

References

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