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CB-002

Chemical Structure : CB-002

CAS No.: 61034-15-9

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CB-002 (CB002)

Catalog No.: PC-60218Not For Human Use, Lab Use Only.

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
    CB-002 (CB002) increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death.
    CB-002 (CB002) decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

    Physicochemical Properties

    M.Wt 271.28
    Formula C13H13N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-Anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

    References

    1. Hernandez-Borrero LJ, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1346762.

    2. Richardson C, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1356514.

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