Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-MDM2-p53-CB-002
CB-002

Chemical Structure : CB-002

CAS No.: 61034-15-9

CB-002 (CB002)

Catalog No.: PC-60218Not For Human Use, Lab Use Only.

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
    CB-002 (CB002) increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death.
    CB-002 (CB002) decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

    Physicochemical Properties

    M.Wt 271.28
    Formula C13H13N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-Anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

    References

    1. Hernandez-Borrero LJ, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1346762.

    2. Richardson C, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1356514.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: