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MK-8242

Chemical Structure : MK-8242

CAS No.:

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MK-8242 (SCH-900242;SCH 900242;MK 8242)

Catalog No.: PC-60262Not For Human Use, Lab Use Only.

A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction; stabilizes the tumor suppressor TP53 and induces growth arrest or apoptosis downstream of TP53 induction; has an IC50 of 70 nM for TP53 wild-type cell lines versus >10 uM for TP53 mutant cell lines.

Blood Cancer

Phase 1 Clinical

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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