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Chemical Structure : MK-8242
Catalog No.: PC-60262Not For Human Use, Lab Use Only.
A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction.
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A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction; stabilizes the tumor suppressor TP53 and induces growth arrest or apoptosis downstream of TP53 induction; has an IC50 of 70 nM for TP53 wild-type cell lines versus >10 uM for TP53 mutant cell lines.
Blood Cancer
Phase 1 Clinical
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| Appearance | Solid | |
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10 mM in DMSO |
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