NU-8231 |CAS:878022-36-7 Probechem Biochemicals

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Chemical Structure : NU-8231

NU-8231 (NU8231;NU 8231)

Catalog No.: PC-60437Not For Human Use, Lab Use Only.

NU-8231 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NU-8231 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.
NU-8231 induces p53-dependent gene transcription SJSA human sarcoma cell line.

Physicochemical Properties

M.Wt	467.95
Formula	C26H26ClNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one

References

1. Hardcastle IR, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1515-20.

2. Hardcastle IR, et al. J Med Chem. 2011 Mar 10;54(5):1233-43.

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NU-8231 (NU8231;NU 8231)

Biological Activity

Physicochemical Properties

References

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