RO5353 | p53-MDM2 inhibitor | Probechem Biochemicals

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Chemical Structure : RO5353

RO5353 (RO-5353)

Catalog No.: PC-60304Not For Human Use, Lab Use Only.

RO5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RO5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.
RO-5353 exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994.
RO-5353 displays tumor regression in tumor models at 10 mg/kg.

Physicochemical Properties

M.Wt	619.533
Formula	C29H29Cl2FN4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

References

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.

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RO5353 (RO-5353)

Biological Activity

Physicochemical Properties

References

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