Catalog No.: PC-23748Not For Human Use, Lab Use Only.
MMRi36 is a MDM2-MDM4 E3 heterodimer E3 ligase activator, binds and stabilizes MDM2-MDM4 RING domain heterodimer (Kd=308 nM, MST assay), promotes proteasomal degradation of MDM2/MDM4 proteins in cells.
MMRi36 is a MDM2-MDM4 E3 heterodimer E3 ligase activator, binds and stabilizes MDM2-MDM4 RING domain heterodimer (Kd=308 nM, MST assay), promotes proteasomal degradation of MDM2/MDM4 proteins in cells. MMRi36 is a potent apoptosis inducer in p53-mutant lymphoma and RRCL cells. MMRi36 is a potent activator of the E3 complex at concentrations as low as 0.31 μM as indicated by increased ubiquitination of MDM4, MDM2B and p53 during in vitro ubiquitination assays. MMRi36 promotes ubiquitination and degradation of MDM2/MDM4/p53 associated with apoptosis induction in cells. MMRi36 promotes XIAP ubiquitination and degradation in cells, induces p53-independent apoptosis.
