MMRi67

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Chemical Structure : MMRi67

Catalog No.: PC-20687Not For Human Use, Lab Use Only.

MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.
MMRi67 inhibited ubiquitination of every component of the ternary complex, MDM2, MDM4, and p53, in a dose-dependent manner.
MMRi67 induced p53 protein accumulation in NALM6 cells, inhibited leukemic cell proliferation with IC50 of 4.58 uM, by inducing p53-independent apoptosis with low toxicity for healthy peripheral blood monocytes (PBMCs).

Physicochemical Properties

M.Wt	405.84
Formula	C22H16ClN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(C(C2=CC(Cl)=C3C=CC=NC3=C2O)NC4=NC=CC=C4)C=C1

References

1. Rati Lama, et al. Front Oncol. 2022 Aug 5;12:933446.

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MMRi67

Biological Activity

Physicochemical Properties

References

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