Chemical Structure : MMRi71
CAS No.:
MMRi71
Catalog No.: PC-20688Not For Human Use, Lab Use Only.
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
MMRi71 exhibits anti-proliferation effect against the wtp53-bearing NALM6 (p53-dependent) and shP53NALM6 (p53-independent) leukemia cell lines with IC50 of 0.23 and 0.29 uM, respectively.
MMRi71 shows strong anti-leukemic activity in the cell proliferation inhibitory assay along with the dose-dependent inhibition of MDM2B E3 ligase activity.
MMRi71 induces MDM2-dependent proteasomal degradation of MDM4 and the lysosome-dependent degradation of FTH1.
MMRi71 effectively kills p53-null leukemia cells, an activity that conventional MDM2-p53 disrupting inhibitors lack.
Physicochemical Properties
|
M.Wt
|
490.94
|
|
Formula
|
C26H23ClN4O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(OCC)C1=CC=C(C(C2=CC(Cl)=C3C=CC=NC3=C2OC(CC)=O)NC4=NC=CC=N4)C=C1
|
References
1. Rati Lama, et al. Molecules. 2022 Nov 8;27(22):7665.
Contact Us
sales@probechem.com
