Chemical Structure : MMRi71
CAS No.:
MMRi71
Catalog No.: PC-20688Not For Human Use, Lab Use Only.
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
MMRi71 exhibits anti-proliferation effect against the wtp53-bearing NALM6 (p53-dependent) and shP53NALM6 (p53-independent) leukemia cell lines with IC50 of 0.23 and 0.29 uM, respectively.
MMRi71 shows strong anti-leukemic activity in the cell proliferation inhibitory assay along with the dose-dependent inhibition of MDM2B E3 ligase activity.
MMRi71 induces MDM2-dependent proteasomal degradation of MDM4 and the lysosome-dependent degradation of FTH1.
MMRi71 effectively kills p53-null leukemia cells, an activity that conventional MDM2-p53 disrupting inhibitors lack.
Physicochemical Properties
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M.Wt
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490.94
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Formula
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C26H23ClN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(OCC)C1=CC=C(C(C2=CC(Cl)=C3C=CC=NC3=C2OC(CC)=O)NC4=NC=CC=N4)C=C1
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References
1. Rati Lama, et al. Molecules. 2022 Nov 8;27(22):7665.
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