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NSC146109

Chemical Structure : NSC146109

CAS No.: 740031-90-7

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NSC146109 (XI-011)

Catalog No.: PC-21746Not For Human Use, Lab Use Only.

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
    NSC146109 (XI-011) activates p53 by increasing its stability, significantly extends the half-life of p53.
    NSC146109 (XI-011) (0.5 uM) induces apoptosis in breast cancer cell MCF-7.
    NSC146109 (XI-011) inhibits MDMX gene transcription, decreases the viability of breast cancer cells expressing a low level of MDMX in a less-efficient manner.
    NSC146109 (XI-011) decreases the viability of breast cancer cells in collaboration with Nutlin-3a.

    Physicochemical Properties

    M.Wt 280.39
    Formula C17H16N2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (10-methylanthracen-9-yl)methyl carbamimidothioate

    References

    1. Hongbo Wang, et al. Neoplasia. 2011 Jul;13(7):611-9.

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