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NSC146109

Chemical Structure : NSC146109

CAS No.: 740031-90-7

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NSC146109 (XI-011)

Catalog No.: PC-21746Not For Human Use, Lab Use Only.

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
NSC146109 (XI-011) activates p53 by increasing its stability, significantly extends the half-life of p53.
NSC146109 (XI-011) (0.5 uM) induces apoptosis in breast cancer cell MCF-7.
NSC146109 (XI-011) inhibits MDMX gene transcription, decreases the viability of breast cancer cells expressing a low level of MDMX in a less-efficient manner.
NSC146109 (XI-011) decreases the viability of breast cancer cells in collaboration with Nutlin-3a.

Physicochemical Properties

M.Wt 280.39
Formula C17H16N2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(10-methylanthracen-9-yl)methyl carbamimidothioate

References

1. Hongbo Wang, et al. Neoplasia. 2011 Jul;13(7):611-9.

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