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Chemical Structure : NSC146109
Catalog No.: PC-21746Not For Human Use, Lab Use Only.
NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
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NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
NSC146109 (XI-011) activates p53 by increasing its stability, significantly extends the half-life of p53.
NSC146109 (XI-011) (0.5 uM) induces apoptosis in breast cancer cell MCF-7.
NSC146109 (XI-011) inhibits MDMX gene transcription, decreases the viability of breast cancer cells expressing a low level of MDMX in a less-efficient manner.
NSC146109 (XI-011) decreases the viability of breast cancer cells in collaboration with Nutlin-3a.
| M.Wt | 280.39 | |
| Formula | C17H16N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hongbo Wang, et al. Neoplasia. 2011 Jul;13(7):611-9.
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