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AM-6761

Chemical Structure : AM-6761

CAS No.: 1584732-36-4

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AM-6761 (AM 6761;AM6761)

Catalog No.: PC-60440Not For Human Use, Lab Use Only.

AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.
    AM-6761 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 11 mg/kg.

    Physicochemical Properties

    M.Wt 695.686
    Formula C33H37Cl2FN2O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(((3R,5R,6S)-1-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)- 6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)methyl)thiazol-5-yl)acetic Acid

    References

    1. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88.

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