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AM-8553

Chemical Structure : AM-8553

CAS No.: 1352064-70-0

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AM-8553 (AM8553;AM 8553)

Catalog No.: PC-60441Not For Human Use, Lab Use Only.

AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.
    AM-8553 exhibits excellent pharmacokinetic properties and in vivo efficacy.

    Physicochemical Properties

    M.Wt 478.41
    Formula C25H29Cl2NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-3-methyl-2-oxo-3-piperidineacetic acid

    References

    1. Rew Y, et al. J Med Chem. 2012 Jun 14;55(11):4936-54.

    2. Bernard D, et al. J Med Chem. 2012 Jun 14;55(11):4934-5.

    3. Lucas BS, et al. J Am Chem Soc. 2012 Aug 1;134(30):12855-60.

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