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Chemical Structure : CTX-1
Catalog No.: PC-60466Not For Human Use, Lab Use Only.
A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
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CTX-1 (NSC 363260) is a small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
CTX-1 results in the rapid induction of p53 in a DNA damage-independent manner, induces apoptosis or suppresses proliferation in a panel of cancer cells (LD50=1-10 uM).
CTX-1 exhibits high in vivo activity in a mouse model of circulating primary human leukemia.
| M.Wt | 234.26 | |
| Formula | C14H10N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Karan G, et al. Mol Cancer Ther. 2016 Apr;15(4):574-582.
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