Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-MDM2-p53-CTX-1
CTX-1

Chemical Structure : CTX-1

CAS No.: 501935-96-2

Add to Favorites

CTX-1 (CTX1;NSC 363260)

Catalog No.: PC-60466Not For Human Use, Lab Use Only.

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CTX-1 (NSC 363260) is a small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
    CTX-1 results in the rapid induction of p53 in a DNA damage-independent manner, induces apoptosis or suppresses proliferation in a panel of cancer cells (LD50=1-10 uM).
    CTX-1 exhibits high in vivo activity in a mouse model of circulating primary human leukemia.

    Physicochemical Properties

    M.Wt 234.26
    Formula C14H10N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,6-diaminoacridine-9-carbonitrile

    References

    1. Karan G, et al. Mol Cancer Ther. 2016 Apr;15(4):574-582.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: