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CTX-1

Chemical Structure : CTX-1

CAS No.: 501935-96-2

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CTX-1 (CTX1;NSC 363260)

Catalog No.: PC-60466Not For Human Use, Lab Use Only.

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CTX-1 (NSC 363260) is a small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
    CTX-1 results in the rapid induction of p53 in a DNA damage-independent manner, induces apoptosis or suppresses proliferation in a panel of cancer cells (LD50=1-10 uM).
    CTX-1 exhibits high in vivo activity in a mouse model of circulating primary human leukemia.

    Physicochemical Properties

    M.Wt 234.26
    Formula C14H10N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,6-diaminoacridine-9-carbonitrile

    References

    1. Karan G, et al. Mol Cancer Ther. 2016 Apr;15(4):574-582.

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