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DS-5272

Chemical Structure : DS-5272

CAS No.: 1235575-97-9

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DS-5272 (DS 5272;DS5272)

Catalog No.: PC-60481Not For Human Use, Lab Use Only.

DS-5272 is a potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS-5272 is a potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.
    DS-5272 inhibits SJSA-1 cell proliferation with GI50 of 0.17 uM, demonstrates excellent antitumor efficacy on SJSA-1 xenografted models with high safety and good PK profiles.

    Physicochemical Properties

    M.Wt 703.675
    Formula C34H38Cl2F2N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b]thiazol-2-yl)((2S,4R)-2-((R)-6-ethyl-4,7-diazaspiro[2.5]octane-7-carbonyl)-4-fluoropyrrolidin-1-yl)methanone

    References

    1. Miyazaki M, et al. Bioorg Med Chem. 2015 May 15;23(10):2360-7.

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