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AM-8735

Chemical Structure : AM-8735

CAS No.: 1429386-01-5

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AM-8735 (AM 8735;AM8735)

Catalog No.: PC-60442Not For Human Use, Lab Use Only.

AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.
    AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with ED50 of 41 mg/kg.

    Physicochemical Properties

    M.Wt 568.506
    Formula C27H31Cl2NO6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((2R,5R,6R)-4-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2- yl)acetic Acid

    References

    1. Gonzalez AZ, et al. J Med Chem. 2014 Mar 27;57(6):2472-88.

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