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J012-3168

Chemical Structure : J012-3168

CAS No.: 1287116-69-1

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J012-3168 (RPL11-MDM2 inhibitor S9)

Catalog No.: PC-20010Not For Human Use, Lab Use Only.

RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation.
    S9 stabilizes p53 and increases p53 transcriptional activity.
    S9 inhibits cancer cell proliferation in vitro and in vivo, induces cell cycle arrest and apoptosis.

    Physicochemical Properties

    M.Wt 376.42
    Formula C21H20N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(6-oxo-1-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-4-yl)phenoxy)acetamide

    References

    1. Bingwu Wang, et al. Mol Med. 2022 Sep 7;28(1):109.

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