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Chemical Structure : Brigimadlin
CAS No.: 2095116-40-6
Catalog No.: PC-20668Not For Human Use, Lab Use Only.
BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $288 | In stock | |
| 5 mg | $498 | In stock | |
| 10 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Brigimadlin (BI 907828) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
BI 907828 decreases viability and induces cell death at picomolar concentrations, in both MDM2 amplified and normal copy number, TP53 wild-type BTSC lines.
BI 907828 (50mg/kg p.o.) treatment resulted in strong activation of p53 target genes p21 and MIC1 in orthotopic tumor-bearing SCID mice.
| M.Wt | 591.46 | |
| Formula | C31H25Cl2FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,3'S,3a'S,10a'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-6'-methyl-2-oxo-3',3a',10',10a'-tetrahydro-1'H-spiro[indoline-3,2'-pyrrolo[2',3':4,5]pyrrolo[1,2-b]indazole]-7'-carboxylic acid |
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1. Xiaoguang Hao, et al. Neuro Oncol. 2022 Dec 15;noac271.
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