PK5196

Chemical Structure : PK5196

Catalog No.: PC-25763Not For Human Use, Lab Use Only.

PK5196 is a small molecule p53 Y220C reactivator and p53 Y220C binder (SPR Kd=6.88 uM), effectively increase the thermal stability of p53 Y220C protein.

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Biological Activity

PK5196 is a small molecule p53 Y220C reactivator and p53 Y220C binder (SPR Kd=6.88 uM), effectively increase the thermal stability of p53 Y220C protein.

Physicochemical Properties

M.Wt	517.46
Formula	C25H32IN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(diethylamino)piperidin-1-yl)methyl)-6-iodo-4-(3-(phenylamino)prop-1-yn-1-yl)phenol

References

1. Rainer Wilcken, et al. J Am Chem Soc. 2012 Apr 18;134(15):6810-8.

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PK5196

Biological Activity

Physicochemical Properties

References

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