TH9028 | MTHFD2 inhibitor | Probechem Biochemicals

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Chemical Structure : TH9028

TH9028 (TH-9028)

Catalog No.: PC-72939Not For Human Use, Lab Use Only.

TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.

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Biological Activity

TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.
TH9028demonstrated efficacy on HL-60 cell viability with EC50 of 11 nM.
TH9028 potently inhibits related MTHFD proteins MTHFD2L and MTHFD1-(DC) with IC50 of 47 and 16 nM, respectively.

Physicochemical Properties

M.Wt	458.399
Formula	C16H18N12O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(5-(3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)ureido)picolinamido)-4-(1H-tetrazol-5-yl)butanoic acid

References

1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.

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TH9028 (TH-9028)

Biological Activity

Physicochemical Properties

References

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