Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Antifolate-TH7299
TH7299

Chemical Structure : TH7299

CAS No.: 1415648-20-2

Add to Favorites

TH7299 (TH 7299)

Catalog No.: PC-47090Not For Human Use, Lab Use Only.

TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.
    TH7299 is a highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).
    TH7299 is a potent inhibitor of the structurally related MTHFD2 isoforms MTHFD2L (IC50: 126 nM) and MTHFD1-DC (IC50: 89 nM).

    Physicochemical Properties

    M.Wt 433.381
    Formula C17H19N7O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-(3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)ureido)benzoyl)-L-glutamic acid

    References

    1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.

    2. Benramdane S, et al. ChemMedChem. 2022 Jun 27:e202200097.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: