TH7299 | MTHFD2 inhibitor | Probechem Biochemicals

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Chemical Structure : TH7299

TH7299 (TH 7299)

Catalog No.: PC-47090Not For Human Use, Lab Use Only.

TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.

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Biological Activity

TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM.
TH7299 is a highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).
TH7299 is a potent inhibitor of the structurally related MTHFD2 isoforms MTHFD2L (IC50: 126 nM) and MTHFD1-DC (IC50: 89 nM).

Physicochemical Properties

M.Wt	433.381
Formula	C17H19N7O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)ureido)benzoyl)-L-glutamic acid

References

1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.

2. Benramdane S, et al. ChemMedChem. 2022 Jun 27:e202200097.

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TH7299 (TH 7299)

Biological Activity

Physicochemical Properties

References

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