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Chemical Structure : Thymidylate synthase destabilizer E7
Catalog No.: PC-49578Not For Human Use, Lab Use Only.
Thymidylate synthase destabilizer E7 is a small molecule human thymidylate synthase (hTS) destabilizer, binds at the monomer-monomer interface and shifts the dimerization equilibrium of both the recombinant and the intracellular protein toward the inactive monomers.
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Thymidylate synthase destabilizer E7 is a small molecule human thymidylate synthase (hTS) destabilizer, binds at the monomer-monomer interface and shifts the dimerization equilibrium of both the recombinant and the intracellular protein toward the inactive monomers.
E7 induced apoptosis in cancer cells and a decrease of hTS levels due to enhanced proteasomal degradation of the enzyme monomers with respect to the dimers.
E7 caused a higher reduction of cancer growth and had lower toxicity than 5-fluorouracil (5-FU), the prodrug of 5-FdUMP, in a mouse model of orthotopic pancreatic cancer.
| M.Wt | 499.57 | |
| Formula | C22H17N3O5S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Costantino L, et al. Elife. 2022 Dec 7;11:e73862.
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