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Plevitrexed

Chemical Structure : Plevitrexed

CAS No.: 153537-73-6

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Plevitrexed (BGC 9331, ZD9331)

Catalog No.: PC-49047Not For Human Use, Lab Use Only.

Plevitrexed (ZD 9331, BGC 9331) is a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Plevitrexed (ZD 9331, BGC 9331) is a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM.
    Plevitrexed selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.

    Physicochemical Properties

    M.Wt 532.53
    Formula C26H25FN8O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(4-(((2,7-dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-2-fluorobenzamido)-4-(1H-tetrazol-5-yl)butanoic acid

    References

    1. Jackman AL, et al. Clin Cancer Res. 1997 Jun;3(6):911-21.

    2. Jackman AL, et al. Adv Exp Med Biol. 1994;370:185-8.

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