| Cat. No. |
Product Name |
Information |
| PC-20655 |
WR99210
DHFR inhibitor
|
WR99210 is an effective inhibitor of dihydrofolate reductase (DHFR) with IC50 of <0.075 nM, shows activity agianst pyrimethamine-resistant P. falciparum strains. |
| PC-49578 |
Thymidylate synthase destabilizer E7
hTS-dimer destabilizer
|
Thymidylate synthase destabilizer E7 is a small molecule human thymidylate synthase (hTS) destabilizer, binds at the monomer-monomer interface and shifts the dimerization equilibrium of both the recombinant and the intracellular protein toward the inactive monomers. |
| PC-49050 |
AGF94
Antifolate
|
AGF94 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49049 |
AGF154
Antifolate
|
AGF154 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49048 |
ONX0801
Antifolate
|
ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC). |
| PC-49047 |
Plevitrexed
Antifolate
|
Plevitrexed (ZD 9331, BGC 9331) is a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM. |
| PC-47090 |
TH7299
MTHFD2 inhibitor
|
TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM. |
| PC-73018 |
DS18561882
MTHFD2 inhibitor
|
DS18561882 (DS 18561882, DS18) is a potent, isozyme-selective, orally available MTHFD2 inhibitor with IC50 of 6.3 nM, >800-fold selectivity over MTHFD1. |
| PC-73015 |
DS44960156
MTHFD2 inhibitor
|
DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM). |
| PC-72940 |
TH9619
MTHFD2 inhibitor
|
TH9619 (TH-9619) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 47 nM. |
| PC-72939 |
TH9028
MTHFD2 inhibitor
|
TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM. |
| PC-62007 |
LSN 3213128
AICARFT inhibitor
|
LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT. |
