| Cat. No. |
Product Name |
Information |
| PC-70211 |
LY345899
MTHFD1/2 inhibitor
|
LY345899 (LY 345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively. |
| PC-42556 |
Trimetrexate
DHFR inhibitor
|
Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor. |
| PC-23433 |
UCP1162
DHFR inhibitor
|
UCP1162 is a potent propargyl-linked inhibitor of dihydrofolate reductase (DHFR) with IC50 of 21.8 nM for inhibition of DHFR to catalyze the NADPH-dependent reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). |
| PC-63364 |
TNP-351
|
TNP-351 is an antifolate compound that functions as a DHFR inhibitor, strongly inhibits the growth of Meth A cells.. |
| PC-60506 |
Arfolitixorin
|
A novel antifolate modulator compound.. |
| PC-45348 |
Calcium N5-methyltetrahydrofolate
|
The calcium salt of levomefolic acid that has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. . |
| PC-42590 |
Pralatrexate
|
An antifolate that fuctions as a dihydrofolate reductase inhibitor for treatment of several malignancies.. |
| PC-42710 |
Pemetrexed disodium
|
A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively. |
| PC-42709 |
Pemetrexed
|
A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively. |
| PC-45206 |
Levomefolate calcium
|
A calcium salt of levomefolic acid.. |
