Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Trimetrexate
CAS No.: 52128-35-5
Catalog No.: PC-42556Not For Human Use, Lab Use Only.
Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.
Trimetrexate shows activity against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.
| M.Wt | 369.4176 | |
| Formula | C19H23N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- |
|
1. Weir EC, et al. Cancer Res. 1982 May;42(5):1696-702.
2. Diddens H, et al. Cancer Res. 1983 Nov;43(11):5286-92.
3. Elslager EF, et al. J Med Chem. 1983 Dec;26(12):1753-60.
4. Wong BK, et al. Drug Metab Dispos. 1990 Nov-Dec;18(6):980-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
