A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.
Chemotherapeutic Agents
Approved
Physicochemical Properties
M.Wt
471.3743
Formula
C20H19N5Na2O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: 11.19 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES
L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2)
References
1. Shih C, et al. Cancer Res. 1997 Mar 15;57(6):1116-23.
2. Tonkinson JL, et al. Cancer Res. 1999 Aug 1;59(15):3671-6.
3. Curtin NJ, et al. Lancet Oncol. 2001 May;2(5):298-306.
