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Chemical Structure : UCP1162
Catalog No.: PC-23433Not For Human Use, Lab Use Only.
UCP1162 is a potent propargyl-linked inhibitor of dihydrofolate reductase (DHFR) with IC50 of 21.8 nM for inhibition of DHFR to catalyze the NADPH-dependent reduction of dihydrofolate (DHF) to tetrahydrofolate (THF).
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UCP1162 is a potent propargyl-linked inhibitor of dihydrofolate reductase (DHFR) with IC50 of 21.8 nM for inhibition of DHFR to catalyze the NADPH-dependent reduction of dihydrofolate (DHF) to tetrahydrofolate (THF).
UCP1162 inhibits a panel of cancer cell lines previously reported to be sensitive to antifolates (HCT116, CCRF-CEM, THP-1, and MV-4–11). with iC50 of 0.78-3.3 nM.
UCP1162 also inhibits cancer cell proliferation and bound cellular DHFR at low nanomolar concentrations.
UCP1162 reduced acute inflammation in mice and inhibited FLS cell growth and motility.
| M.Wt | 412.50 | |
| Formula | C24H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ozcan Tezgin D, et al. Biochem Pharmacol. 2024 Nov 9;230(Pt 3):116617.
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