JNJ-pan-AR

Chemical Structure : JNJ-pan-AR

Catalog No.: PC-72512Not For Human Use, Lab Use Only.

JNJ-pan-AR is a highly potent, selective antagonist of androgen receptor (AR) wild-type and F877L mutant for the treatment of the F877L mutant and wild-type CRPC.

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Biological Activity

JNJ-pan-AR is a highly potent, selective antagonist of androgen receptor (AR) wild-type and F877L mutant for the treatment of the F877L mutant and wild-type CRPC.

Physicochemical Properties

M.Wt	515.555
Formula	C25H24F3N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-(4-((1-methylpiperidin-4-yl)oxy)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

References

1. Zhang Z, et al. ACS Med Chem Lett. 2021 Jun 29;12(8):1245-1252.

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JNJ-pan-AR

Biological Activity

Physicochemical Properties

References

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